Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial.

Miguel Á Ibarra-EstradaEduardo KattanPavel Aguilera-GonzálezLaura Sandoval-PlascenciaUriel Rico-JaureguiCarlos A Gómez-PartidaIris X Ortiz-MacíasJosé A López-PulgarínQuetzalcóatl Chávez-PeñaJulio C Mijangos-MéndezGuadalupe Aguirre-AvalosGlenn Hernández

Published in: Critical care (London, England) (2023)

In patients with septic shock, MB initiated within 24 h reduced time to vasopressor discontinuation and increased vasopressor-free days at 28 days. It also reduced length of stay in ICU and hospital without adverse effects. Our study supports further research regarding MB in larger randomized clinical trials. Trial registration ClinicalTrials.gov registration number NCT04446871 , June 25, 2020, retrospectively registered.

Keyphrases

septic shock
intensive care unit
healthcare
clinical trial
study protocol
randomized controlled trial
emergency department
mechanical ventilation
adverse drug
open label