Distinct fecal and oral microbiota composition in human type 1 diabetes, an observational study.
Pieter F de GrootClara BelzerÖmrüm AydinEvgeni LevinJohannes H LevelsSteven AalvinkFransje BootFrits HollemanDaniël H van RaalteTorsten P ScheithauerSuat SimsekFrank G SchaapSteven W M Olde DaminkBart O RoepJoost B HoekstraWillem M de VosMax NieuwdorpPublished in: PloS one (2017)
We conclude that T1D patients harbor a different amount of intestinal SCFA (butyrate) producers and different plasma acetate and propionate levels. Future research should disentangle cause and effect and whether supplementation of SCFA-producing bacteria or SCFA alone can have disease-modifying effects in T1D.
Keyphrases