Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma.

Ritsuko Iwanaga Tomomi M Yamamoto Karina Gomez Lily L Nguyen Elizabeth R Woodruff Miriam D Post Railey G Mikeska Etienne Danis Laura D Harmacek Meher Preethi Boorgula Siddhartha S Mitra Nicole A Marjon Benjamin G Bitler Lindsay W Brubaker

Published in: Cancer research communications (2024)

CBX2 expression correlates with the TIME. CBX2 modulation shifts the macrophage population, potentially leading to an immunosuppressive microenvironment, highlighting CBX2 as a target to improve efficacy of immunotherapy.

Keyphrases

high grade
low grade
poor prognosis
stem cells
adipose tissue
binding protein