Regulatory network identified by pulmonary transcriptome and proteome profiling reveals extensive change of tumor-related genes in microRNA-21 knockout mice.

Ge Luan Ming Wang Jing Yuan Xiangting Bu Jing Song Chengshuo Wang Luo Zhang

Published in: Journal of cancer research and clinical oncology (2022)

MiR-21-gene regulatory network was constructed in mouse lung tissue. MiR-21KO resulted in extensive upregulation of tumor suppressor genes and downregulation of oncogenes.

Keyphrases

cell proliferation
long non coding rna
genome wide
long noncoding rna
single cell
poor prognosis
pulmonary hypertension
signaling pathway
wastewater treatment
rna seq
transcription factor
dna methylation
network analysis
bioinformatics analysis