Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
Neda RasouliNaji YounesAlokananda GhoshJeanine AlbuRobert M CohenRalph A De FronzoElsa DiazLaure Sayyed KassemJosé A LuchsingerJanet B McGillWilliam I SivitzWilliam V TamborlaneKristina M UtzschneiderSteven E Kahnnull nullPublished in: Diabetes care (2024)
The differential long-term effects on insulin sensitivity and β-cell function of four different glucose-lowering medications when added to metformin highlight the importance of the loss of β-cell function in the progression of type 2 diabetes.