Bexarotene leads to durable improvements in visual evoked potential latency: A follow-up study of the Cambridge Centre for Myelin Repair One trial.
Christopher E McMurranTrisha MukherjeeJames William L BrownAlasdair J ColesNicholas G CunniffePublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2024)
The Cambridge Centre for Myelin Repair One (CCMR-One) trial showed that 6 months of bexarotene reduces visual evoked potential (VEP) latency in people with relapsing-remitting multiple sclerosis (MS). In a single-centre follow-up study of these participants, we re-examined full-field VEP and clinical assessments. Twenty participants (12 bexarotene and 8 placebo) were seen on average 27 months after their trial involvement. In an analysis of all eyes with recordable signal (24 bexarotene and 14 placebo), the adjusted bexarotene-placebo treatment difference in P100 latency was -7.79 (95% confidence interval (CI) = -14.76, -0.82) ms, p = 0.044. We conclude that there were durable improvements in VEP latency, suggesting long-term benefits from exposure to a remyelinating drug.
Keyphrases
- multiple sclerosis
- phase iii
- white matter
- open label
- clinical trial
- phase ii
- study protocol
- double blind
- placebo controlled
- mass spectrometry
- ms ms
- risk assessment
- human health
- randomized controlled trial
- emergency department
- rheumatoid arthritis
- optical coherence tomography
- disease activity
- climate change
- smoking cessation