Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors.

Francesca PaoliniCarla AmiciMariantonia CarosiClaudia BonomoPaola Di BonitoAldo VenutiLuisa Accardi

Published in: Journal of experimental & clinical cancer research : CR (2021)

Based on our study, two scFvs have been identified that could represent a safe and effective treatment for the therapy of HPV16-associated lesions. The mechanism underlying the scFv effectiveness appears to be leading cells towards death by apoptosis. Furthermore, the validity of electroporation, a methodology allowed for human treatment, to deliver scFvs to tumors was confirmed.

Keyphrases

cell cycle arrest
randomized controlled trial
endothelial cells
induced apoptosis
high grade
oxidative stress
endoplasmic reticulum stress
signaling pathway
cancer therapy
induced pluripotent stem cells
smoking cessation