A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids.

Jan WysockiMinghao YeLuise HasslerAshwani Kumar GuptaYuguo WangVlad NicoleascuGlenn RandallJason A WertheimDaniel Batlle

Published in: Journal of the American Society of Nephrology : JASN (2021)

This novel ACE2 1-618-ABD can neutralize SARS-CoV-2 infectivity in human kidney organoids, and its prolonged duration of action should ensure improved efficacy to prevent viral escape and dosing convenience.

Keyphrases

sars cov
induced pluripotent stem cells
endothelial cells
respiratory syndrome coronavirus
pluripotent stem cells
angiotensin ii
angiotensin converting enzyme