Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.
Deepak BabuRamulu ChintalManas PanigrahiPhanithi Prakash BabuPublished in: Cellular oncology (Dordrecht) (2022)
Our data indicate upregulation of BRMS1 in high grade astrocytomas which correlates positively with mutant P53 and a poor patient survival. Silencing of BRMS1 in mutant P53 GBM cell lines resulted in a reduced cellular growth and migration/invasion by suppressing the EGFR-AKT/NF-kB signaling pathway. BRMS1 may serve as a predictive biomarker and therapeutic target in mutant P53 GBM.
Keyphrases
- signaling pathway
- high grade
- wild type
- pi k akt
- poor prognosis
- small cell lung cancer
- cell proliferation
- induced apoptosis
- epithelial mesenchymal transition
- epidermal growth factor receptor
- low grade
- case report
- immune response
- cell migration
- tyrosine kinase
- long non coding rna
- toll like receptor
- machine learning
- artificial intelligence