Functional roles of microRnas in vasculogenic mimicry and resistance to therapy in human cancers: an update.
Alejandra Paola García-HernándezGricelda Sánchez-SánchezAngeles Carlos-ReyesCesar López-CamarilloPublished in: Expert review of clinical immunology (2024)
The miRNAs are regulators of protein-encoding genes involved in VM; however, their specific expression signatures with clinical value in large cohorts of patients have not been established yet. We considered that genomic profiling of miRNAs could be useful to define some hallmarks of tumors such as stemness, drug resistance and VM in cancer patients. However, additional studies are needed to establish the relevant role of miRNAs as effective therapeutic targets in tumors that have developed VM.
Keyphrases
- end stage renal disease
- ejection fraction
- chronic kidney disease
- stem cells
- newly diagnosed
- poor prognosis
- binding protein
- peritoneal dialysis
- prognostic factors
- epithelial mesenchymal transition
- transcription factor
- gene expression
- mesenchymal stem cells
- genome wide
- copy number
- dna methylation
- single cell
- amino acid
- bone marrow