Micelle encapsulation zinc-doped copper oxide nanocomposites reverse Olaparib resistance in ovarian cancer by disrupting homologous recombination repair.
Jingyan YiXin LuoJinshan XingAharon GedankenXiukun LinChunxiang ZhangGan QiaoPublished in: Bioengineering & translational medicine (2023)
Micelle Encapsulation Zinc-doped copper oxide nanocomposites (MEnZn-CuO NPs) is a novel doped metal nanomaterial prepared by our group based on Zinc doped copper oxide nanocomposites (Zn-CuO NPs) using non-micellar beam. Compared with Zn-CuO NPs, MEnZn-CuO NPs have uniform nanoproperties and high stability. In this study, we explored the anticancer effects of MEnZn-CuO NPs on human ovarian cancer cells. In addition to affecting cell proliferation, migration, apoptosis and autophagy, MEnZn-CuO NPs have a greater potential for clinical application by inducing HR repair defects in ovarian cancer cells in combination with poly (ADP-ribose) polymerase inhibitors for lethal effects.
Keyphrases
- oxide nanoparticles
- visible light
- quantum dots
- highly efficient
- cell proliferation
- endoplasmic reticulum stress
- dna damage
- cell death
- metal organic framework
- oxidative stress
- reduced graphene oxide
- dna repair
- endothelial cells
- signaling pathway
- heavy metals
- risk assessment
- carbon nanotubes
- gold nanoparticles
- pluripotent stem cells
- cell cycle
- induced pluripotent stem cells