Longitudinal variation in human immunodeficiency virus long terminal repeat methylation in individuals on suppressive antiretroviral therapy.

César N Cortés-RubioGonzalo Salgado-Montes de OcaFrancisco J Prado-GalbarroMargarita Matías-FlorentinoAkio Murakami-OgasawaraLeticia Kuri-CervantesAna P Carranco-ArenasChristopher E OrmsbyIvette K Cortés-RubioGustavo Reyes-TeránSantiago Avila-Ríos

Published in: Clinical epigenetics (2019)

Our study shows evidence that HIV 5'-LTR methylation in total CD4+ T cells is dynamic along time and that it can follow different temporal patterns that are associated with a combination of baseline and follow-up clinical characteristics. These observations may account for differences observed between previous contrasting studies.

Keyphrases

human immunodeficiency virus
antiretroviral therapy
hiv infected
hiv positive
hiv aids
hiv infected patients
hepatitis c virus
dna methylation
genome wide
cross sectional
south africa
case control