Direct conversion of human fibroblasts to functional excitatory cortical neurons integrating into human neural networks.

Giedre MiskinyteKarthikeyan DevarajuMarita Grønning HansenEmanuela MonniDaniel TorneroNiels Bjarne WoodsJohan BengzonHenrik AhleniusOlle LindvallZaal Kokaia

Published in: Stem cell research & therapy (2017)

Our findings indicate that functional excitatory cortical neurons, generated here for the first time by direct conversion of human somatic cells, have the capacity for synaptic integration into adult human cortex.

Keyphrases

endothelial cells
pluripotent stem cells
neural network
gene expression
induced apoptosis
oxidative stress
dna methylation
young adults
cell death
functional connectivity