Response to Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment".

Roberto Hirochi Herai Ryan A Szeto Cleber A Trujillo Alysson Renato Muotri

Published in: Science (New York, N.Y.) (2021)

Maricic et al. performed an undisclosed in silico-only whole-exome sequencing analysis of our data and found genomic alterations previously undetected in some clones. Some of the predicted alterations, if true, could change the original genotype of the clones. We failed to experimentally validate all but one of these genomic alterations, which did not affect our previous results or data interpretation.

Keyphrases

electronic health record
big data
copy number
gene expression
artificial intelligence