Chaperonology: The Third Eye on Brain Gliomas.
Francesca GrazianoC Caruso BavisottoA Marino GammazzaFrancesca RappaEverly Conway de MacarioAlbert J L MacarioFrancesco CappelloClaudia CampanellaRosario MaugeriDomenico Gerardo IacopinoPublished in: Brain sciences (2018)
The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents.
Keyphrases
- heat shock
- high grade
- phase iii
- low grade
- open label
- clinical trial
- heat stress
- heat shock protein
- ejection fraction
- phase ii
- end stage renal disease
- white matter
- resting state
- newly diagnosed
- early stage
- high resolution
- heart rate
- double blind
- cerebral ischemia
- oxidative stress
- placebo controlled
- single molecule
- working memory
- study protocol
- squamous cell carcinoma
- gene expression
- randomized controlled trial
- genome wide
- multiple sclerosis
- mass spectrometry
- free survival
- radiation induced
- subarachnoid hemorrhage
- copy number
- combination therapy