Dissecting the Domains of Parkinson's Disease: Insights from Longitudinal Item Response Theory Modeling.
Sheng LuoHaotian ZouGlenn T StebbinsMichael A SchwarzschildEric A MacklinJames ChanDavid OakesTanya SimuniChristopher G Goetznull nullPublished in: Movement disorders : official journal of the Movement Disorder Society (2022)
Longitudinal IRT analysis is a novel statistical method addressing limitations of traditional linear regression approaches. It is particularly useful because it can simultaneously monitor changes in different, but related, domains over time and in response to treatment interventions. We suggest that in neurological diseases with distinct impairment domains, clinical or anatomical, this application may identify patterns of change unappreciated by standard statistical methods. © 2022 International Parkinson and Movement Disorder Society.