Unlocking the diagnostic power of plasma extracellular vesicle miR-200 family in pancreatic ductal adenocarcinoma.
Daniel S K LiuJisce R PuikBhavik Y PatelMorten T VenøMahrou VahabiMireia Mato PradoJason P WebberEleanor ReesFlora M UptonKate BennettCatherine BlakerBenoit ImmordinoAnnalisa ComandatoreLuca MorelliShivan SivakumarRutger-Jan SwijnenburgMarc G BesselinkLong R JiaoGeert KazemierElisa GiovannettiJonathan KrellAdam E FramptonPublished in: Journal of experimental & clinical cancer research : CR (2024)
This is the first study to validate plasma EV-miR-200 members as a clinically-useful diagnostic biomarker for PDAC. Further validation in larger cohorts and clinical trials is essential. These findings also suggest the potential utility in monitoring response and/or recurrence.