Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma.
Mai IwayaHiroyoshi OtaTomoyuki NakajimaTakeshi UeharaRobert RiddellJames ConnerPublished in: BMC cancer (2021)
These findings suggest that the wider spectrum of tumor morphology in CAC may be associated with absence of a LGR5-expressing intestinal stem cell phenotype.