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High levels of perivascular inflammation and active demyelinating lesions at time of death associated with rapidly progressive multiple sclerosis disease course: a retrospective post-mortem cohort study.

Richard St John NicholasRoberta MagliozziDamiano MarastoniOwain HowellFederico RoncaroliPaolo MuraroRichard ReynoldsTim Friede
Published in: Annals of neurology (2023)
ALs, a feature of early disease stage, persist up to death in a subgroup with high levels of PVI. These features link to a rapid progressive phase and higher levels of meningeal inflammation and B-cell infiltrates, supporting the hypothesis that chronic inflammation drives progression in MS. This article is protected by copyright. All rights reserved.
Keyphrases
  • multiple sclerosis
  • oxidative stress
  • white matter
  • mass spectrometry
  • machine learning
  • deep learning
  • study protocol
  • neural network