The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys.

Sheo B SinghLing KangAndrea R NawrockiDan ZhouMargaret WuStephen PrevisCorey MillerHaiying LiuCatherine D G HinesMaria MadeiraJin CaoKithsiri HerathLarry D SpearsClay F SemenkovichLiangsu WangDavid E KelleyCai LiHong-Ping Guan

Published in: PloS one (2016)

These findings demonstrate unique properties of PTM and provide proof-of-concept of FAS inhibition having potential utility for the treatment of diabetes and related metabolic disorders.

Keyphrases

insulin resistance
high fat diet induced
type diabetes
fatty acid
high fat diet
adipose tissue
metabolic syndrome
glycemic control
cardiovascular disease
polycystic ovary syndrome
risk assessment
combination therapy
climate change