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Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues.

Xiaoqing ChangJessica PalmerAnnie LumenUn Jung LeePatricia CegerKamel MansouriCatherine S SprankleElizabeth DonleyShannon M BellThomas B KnudsenJohn F WambaughBethany CookDavid G AllenNicole C Kleinstreuer
Published in: Birth defects research (2022)
human stem cell-based platform to quantitatively assess a chemical's developmental toxicity potency.
Keyphrases
  • stem cells
  • endothelial cells
  • oxidative stress
  • induced pluripotent stem cells
  • high throughput
  • molecular docking
  • high resolution
  • pluripotent stem cells
  • oxide nanoparticles
  • single cell