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How much of the outcome improvement after successful recanalization is explained by follow-up infarct volume reduction?

Helge C KniepLukas MeyerGabriel BroocksMatthias BechsteinFriederike AusteinRosalie V McDonoughCaspar BrekenfeldFabian Alexander FlottmannMilani Deb-ChatterjiAnna AlegianiUta HanningGoetz ThomallaFiehler JensSusanne Gellissen
Published in: Journal of neurointerventional surgery (2023)
56% (95% CI 38% to 78%) of outcome improvement after successful recanalization was explained by FIV reduction. Results corroborate pathophysiological assumptions and confirm the value of FIV as an imaging endpoint in clinical trials. 44% (95% CI 22% to 62%) of the improvement in outcome was not explained by FIV reduction and reflects the remaining mismatch between radiological and clinical outcome measures.
Keyphrases
  • clinical trial
  • middle cerebral artery
  • heart failure
  • randomized controlled trial
  • coronary artery disease
  • acute myocardial infarction
  • mass spectrometry
  • atrial fibrillation
  • double blind
  • phase ii