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The Role of the Non-neuronal Cholinergic System in Inflammation and Degradation Processes in Osteoarthritis.

Alice CourtiesAriane DoSarah LeiteManon LegrisLaure SudreAudrey PigenetJuliette PetitGeoffroy NourissatAdeline Cambon-BinderUwe MaskosFrancis BerenbaumJérémie Sellam
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
The non-neuronal cholinergic system is functionally expressed in chondrocytes. Stimulation of nAChR induces antiinflammatory and anticatabolic activity through α7-nAChR, but the anticatabolic activity may be mitigated by truncated α7-nAChR in human chondrocytes. In vivo experiments strongly suggest that α7-nAChR has a protective role in OA.
Keyphrases
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