The Role of the Non-neuronal Cholinergic System in Inflammation and Degradation Processes in Osteoarthritis.
Alice CourtiesAriane DoSarah LeiteManon LegrisLaure SudreAudrey PigenetJuliette PetitGeoffroy NourissatAdeline Cambon-BinderUwe MaskosFrancis BerenbaumJérémie SellamPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
The non-neuronal cholinergic system is functionally expressed in chondrocytes. Stimulation of nAChR induces antiinflammatory and anticatabolic activity through α7-nAChR, but the anticatabolic activity may be mitigated by truncated α7-nAChR in human chondrocytes. In vivo experiments strongly suggest that α7-nAChR has a protective role in OA.