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CD81 is a novel immunotherapeutic target for B cell lymphoma.

Felipe Vences-CatalánChiung-Chi KuoRanjani RajapaksaCaroline DuaultNoemi AndorDebra K CzerwinskiRonald LevyShoshana Levy
Published in: The Journal of experimental medicine (2019)
The tetraspanin CD81 was initially discovered by screening mAbs elicited against a human B cell lymphoma for their direct antiproliferative effects. We now show that 5A6, one of the mAbs that target CD81, has therapeutic potential. This antibody inhibits the growth of B cell lymphoma in a xenograft model as effectively as rituximab, which is a standard treatment for B cell lymphoma. Importantly, unlike rituximab, which depletes normal as well as malignant B cells, 5A6 selectively kills human lymphoma cells from fresh biopsy specimens while sparing the normal lymphoid cells in the tumor microenvironment. The 5A6 antibody showed a good safety profile when administered to a mouse transgenic for human CD81. Taken together, these data provide the rationale for the development of the 5A6 mAb and its humanized derivatives as a novel treatment against B cell lymphoma.
Keyphrases
  • diffuse large b cell lymphoma
  • endothelial cells
  • induced pluripotent stem cells
  • pluripotent stem cells
  • induced apoptosis
  • nk cells
  • cell death
  • cell cycle arrest
  • minimally invasive
  • robot assisted
  • smoking cessation