In vitro selection of DNA aptamers against human osteosarcoma.
Khaliunsarnai TsogtbaatarDiana A SousaDebora FerreiraAtakan TevlekHalil Murat AydınEda ÇelikLigia R RodriguesPublished in: Investigational new drugs (2021)
These results suggest that OS-7.9 could recognize a common protein expressed in these cancer cells, possibly becoming a potential molecular probe for early diagnosis and targeted therapies for metastatic disease. Moreover, to the best of our knowledge, this was the first attempt to generate a DNA aptamer (OS-7.9 aptamer) against the MG-63-cell line by cell-SELEX.
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