Intra-silicone Oil Injection of Methotrexate in Retinal Reattachment Surgery for Proliferative Vitreoretinopathy.
Khalil Ghasemi FalavarjaniAli HadavandkhaniMohammad Mehdi ParvareshMehdi ModarresMasood NaseripourSayyed Amirpooya AlemzadehPublished in: Ocular immunology and inflammation (2019)
Purpose: To evaluate the role of intrasilicone oil injection of methotrexate (MTX) at the end of vitrectomy surgery for rhegmatogenous retinal detachment (RRD) associated with proliferative vitreoretinopathy (PVR).Methods: In this prospective comparative study, pars plana vitrectomy and retinal reattachment were performed for eyes with RRD with grade C PVR. In the MTX group, 250 µg MTX was injected into the silicone oil at the end of surgery. The rate of retinal redetachment associated with PVR was assessed.Results: In total, 44 eyes of 44 patients (22 in the MTX group and 22 controls) were included. Baseline characteristics were similar between the two groups. Retinal redetachment occurred in one eye (4.5%) in the MTX group and five eyes (22.7%) in the control group (p = 0.18). The change in visual acuity was similar between the two groups at final visit (p = 0.15).Conclusion: The rate of redetachment associated with PVR was lower after intrasilicone injection of MTX at the end of vitrectomy for RRD with severe PVR compared to control group; however, the difference was not statistically significant.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- minimally invasive
- coronary artery bypass
- optic nerve
- end stage renal disease
- ejection fraction
- high dose
- fatty acid
- chronic kidney disease
- ultrasound guided
- prognostic factors
- acute coronary syndrome
- coronary artery disease
- early onset
- low dose
- drug induced
- cataract surgery