Molecular signature of hepatitis B virus regulation by interferon-γ in primary human hepatocytes.

Takuto NosakaTatsushi NaitoHidetaka MatsudaMasahiro OhtaniKatsushi HiramatsuTomoyuki NemotoTsutomu NishizawaHiroaki OkamotoYasunari Nakamoto

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2019)

IFN-γ can suppress HBV propagation and transcription in hepatocytes by activating specific intracellular signaling pathways in hepatocytes, and suggests the future application of these particular signaling pathways or genes for the complete elimination of HBV.

Keyphrases

hepatitis b virus
signaling pathway
liver injury
liver failure
endothelial cells
dendritic cells
pi k akt
drug induced
epithelial mesenchymal transition
induced apoptosis
immune response
genome wide
current status
transcription factor
gene expression
pluripotent stem cells
reactive oxygen species