Characterization of the Tumor Immune Microenvironment Identifies M0 Macrophage-Enriched Cluster as a Poor Prognostic Factor in Hepatocellular Carcinoma.
Mark FarhaNeil K JairathTheodore S LawrenceIssam El NaqaPublished in: JCO clinical cancer informatics (2021)
Distinct immune cell clusters with macrophage predominance characterize an aggressive HCC phenotype, defined molecularly by angiogenic gene enrichment and clinically by poor prognosis and sorafenib response. This novel immunogenomic signature may aid in stratification of unresectable patients to receive checkpoint inhibitor and antiangiogenic therapy combinations.
Keyphrases
- prognostic factors
- poor prognosis
- long non coding rna
- end stage renal disease
- adipose tissue
- genome wide
- stem cells
- chronic kidney disease
- ejection fraction
- dna damage
- peritoneal dialysis
- cell cycle
- patient reported outcomes
- locally advanced
- copy number
- mesenchymal stem cells
- oxidative stress
- rectal cancer
- replacement therapy