Combining value of information analysis and ethical argumentation in decisions on participation of vulnerable patients in clinical research.
Gert Jan van der WiltJanneke P C GruttersAngela H E M MaasHerbert J A RoldenPublished in: BMC medical ethics (2018)
Further clinical research on NOACs in premenopausal women with atrial fibrillation can be justified on both, ethical and economic grounds. Addressing apparent ethical dilemmas by invoking a method such as specifying norms can improve the quality of public practical reasoning. As such, the method should also prove valuable to committees that have formally been granted the authority to review trial protocols and proposals for scientific research.
Keyphrases
- atrial fibrillation
- end stage renal disease
- ejection fraction
- chronic kidney disease
- decision making
- newly diagnosed
- oral anticoagulants
- clinical trial
- prognostic factors
- physical activity
- randomized controlled trial
- mental health
- magnetic resonance imaging
- computed tomography
- phase iii
- phase ii
- health information
- catheter ablation
- social media
- venous thromboembolism
- data analysis