Effects of E4/DRSP on self-reported physical and emotional premenstrual and menstrual symptoms: data from the phase 3 clinical trial in Europe and Russia.

Johannes BitzerCéline BouchardJános ZatikSteven WeyersTerhi PiltonenLarisa SuturinaInna ApolikhinaKristina Gemzell-DanielssonMaud JostMitchell D CreininJean-Michel Foidart

Published in: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception (2024)

E4/DRSP starters experienced significant improvements in the domains Pain, Water Retention and Negative Affect particularly benefiting those with more severe baseline symptoms. Switchers showed minimal changes.

Keyphrases

clinical trial
chronic pain
sleep quality
physical activity
pain management
mental health
early onset
electronic health record
neuropathic pain
big data
open label
phase ii
randomized controlled trial
machine learning
spinal cord injury
phase iii