Long noncoding RNA SNHG7-miRNA-mRNA axes crosstalk with oncogenic signaling pathways in human cancers.
Faezeh MalakotiForough AlemiShirin Jafari YeganehForoogh HosseiniNazila ShabestaniSahar SamemalekiMasomeh MalekiSarvin Fathi DaneshvarMajid MontazerBahman YousefiPublished in: Chemical biology & drug design (2022)
LncRNAs and miRNAs are the two most important non-coding RNAs, which have been identified to be associated with cancer progression or prevention. The dysregulation of lncRNAs conducts tumorigenesis and metastasis in different ways. One of the mechanisms is that lncRNAs interact with miRNAs to regulate distinct cellular and genomic processes and cancer progression. LncRNA SNHG7 as an oncogene sponges miRNAs and develops lncRNA-miRNA-mRNA axes, leading to the regulation of several signaling pathways such as Wnt/β-Catenin, PI3K/AKT/mTOR, SIRT1, and Snail-EMT. Therefore, in this article, after a brief overview of lncRNA SNHG7-miRNA-mRNA axes' contribution to cancer development, we will discuss the role of lncRNA SNHG7 in the genes expression and signaling pathways related to cancers development via acting as a ceRNA.
Keyphrases
- long noncoding rna
- poor prognosis
- long non coding rna
- papillary thyroid
- epithelial mesenchymal transition
- signaling pathway
- squamous cell
- binding protein
- cell proliferation
- stem cells
- endothelial cells
- pi k akt
- oxidative stress
- lymph node metastasis
- squamous cell carcinoma
- genome wide identification
- network analysis
- gene expression
- genome wide
- dna methylation
- copy number
- transcription factor
- induced apoptosis
- induced pluripotent stem cells
- drug induced