MicroRNA-126 protects against vascular injury by promoting homing and maintaining stemness of late outgrowth endothelial progenitor cells.

Chong Zhe PeiBo LiuYe Ting LiLu FangYi ZhangYi Gang LiShu Meng

Published in: Stem cell research & therapy (2020)

Our results indicate that miR-126 protects against vascular injury by promoting CXCR4 expression and LOC homing via ERK/VEGF and Akt/eNOS signaling pathways and maintaining stemness via targeting KLF-8.

Keyphrases

signaling pathway
pi k akt
cell proliferation
epithelial mesenchymal transition
endothelial cells
stem cells
poor prognosis
long non coding rna
vascular endothelial growth factor
induced apoptosis
cancer stem cells
transcription factor
nitric oxide synthase
oxidative stress
binding protein
nitric oxide