Multicenter dose-escalation Phase I trial of mitomycin C pressurized intraperitoneal aerosolized chemotherapy in combination with systemic chemotherapy for appendiceal and colorectal peritoneal metastases: rationale and design.

Mustafa RaoofKevin M SullivanPaul H FrankelMarwan FakihTimothy W SynoldDean LimYanghee WooIsaac Benjamin PazYuman FongRebecca Meera ThomasSue ChangMelissa EngRaechelle TinsleyRichard L WhelanDanielle DeperaltaMarc A ReymondJeremy JonesAmit MercheaThanh H Dellinger

Published in: Pleura and peritoneum (2022)

This Phase I trial will establish the recommended dose of MMC-PIPAC in combination with FOLFIRI. Additionally, we expect to detect an early efficacy signal for further development of this therapeutic combination.

Keyphrases

phase iii
study protocol
clinical trial
phase ii
locally advanced
open label
low grade
squamous cell carcinoma
cross sectional
double blind
chemotherapy induced
high grade