Exposure to inorganic particles in paediatric sarcoidosis: the PEDIASARC study.
Nadia NathanMarie-Emeline MontagneOdile MacchiPaul-André RosentalSimon ChauveauFlorence JenyLucile SeséRola Abou TaamManon BrocvielleJacques BrouardMickaël CatinonCatherine Chapelon-AbricFleur Cohen-AubartChristophe DelacourtCéline DelestrainAntoine DeschildreAntoine DossierRalph EpaudJulien HarocheVéronique HoudouinDominique Israel-BietKarine JuvinSylvain Le JeuneFrancois LionnetUlrich MeinzerMarie MittaineHilario NunesSarah MattioniJean-Marc NaccacheMarie-Hélène OdièvreMichel VincentAnnick ClementDominique ValeyreCatherine Cavalinnull nullPublished in: Thorax (2021)
Inorganic antigens may contribute to paediatric sarcoidosis. Thirty-six patients matched with 36 healthy controls as well as a group of 21 sickle-cell disease (SCD) controls answered an environmental questionnaire. Patients' indirect exposure to inorganic particles, through coresidents' occupations, was higher than in healthy and SCD controls (median score: 2.5 (0.5-7) vs 0.5 (0-2), p=0.003 and 1 (0-2), p=0.012, respectively), especially for construction, exposures to metal dust, talc, abrasive reagents and scouring products. Wood or fossil energies heating were also linked to paediatric sarcoidosis. This study supports a link between mineral environmental exposure due to adult coresident occupations and paediatric sarcoidosis.
Keyphrases
- end stage renal disease
- intensive care unit
- emergency department
- ejection fraction
- sickle cell disease
- newly diagnosed
- chronic kidney disease
- prognostic factors
- human health
- risk assessment
- dendritic cells
- climate change
- patient reported
- cross sectional
- young adults
- heavy metals
- psychometric properties
- health risk assessment
- life cycle
- high density