Effects of haemodynamically atrio-ventricular optimized His-pacing on heart failure symptoms and exercise capacity: The His Optimized Pacing Evaluated for Heart Failure (HOPE-HF) randomised, double-blind, cross-over trial.
Zachary I WhinnettMatthew J Shun-ShinMark TannerPaul FoleyBadri ChandrasekaranPhilip MooreShaumik AdhyaNorman QureshiAmal MuthumalaRebecca LaneAldo RinaldiSharad AgarwalFrancisco LeyvaJonathan BeharSukh BassiAndre NgPaul ScottRachana PrasadJon SwinburnJoseph TomsonAmarjit SethiJaymin ShahPhang Boon LimAndreas KyriacouDewi ThomasJenny ChuenRavi KamdarPrapa KanagaratnamMyril MarivelesLeah BurdenKatherine MarchAhran ArnoldPugazhendhi VijayaramanBerthold StegemannNicholas JohnsonEmanuela FalaschettiDarrel P FrancisJohn Gf ClelandZachary I WhinnettPublished in: European journal of heart failure (2022)
His-bundle pacing did not increase peak oxygen uptake but, under double-blind conditions, significantly improved quality of life and was symptomatically preferred by the clear majority of patients. Ventricular pacing delivered via the His bundle did not adversely impact ventricular function during the 6 months. This article is protected by copyright. All rights reserved.
Keyphrases
- heart failure
- cardiac resynchronization therapy
- left ventricular
- double blind
- clinical trial
- placebo controlled
- phase iii
- study protocol
- phase ii
- acute heart failure
- end stage renal disease
- newly diagnosed
- open label
- ejection fraction
- atrial fibrillation
- chronic kidney disease
- catheter ablation
- prognostic factors
- randomized controlled trial
- peritoneal dialysis
- physical activity
- high intensity
- body composition
- resistance training
- depressive symptoms