Muscle MRI in Patients With Oculopharyngeal Muscular Dystrophy.
Rosemarie H M J M KroonJohanna G KalfBert J M de SwartLinda HeskampJacky W J de RooyBaziel G M van EngelenCorinne G C HorlingsPublished in: Neurology (2023)
According to quantitative muscle MRI, the tongue, adductor magnus and soleus show the largest fat infiltration levels in patients with OPMD. Fat fractions increased in several orofacial and leg muscles over 20 months, with the largest fat fraction increase seen in the soleus. This study supports that this technique is sensitive enough to show worsening in fat fractions of orofacial and leg muscles and therefore a responsive biomarker for future clinical trials.