Increased Incidence of Adverse Events in Diabetes Mellitus Patients with Combined Multiple Vulnerable Plaque Features. New Insights From the COMBINE OCT-FFR trial.
David Del ValBalazs BertaTomasz RolederKrzysztof MalinowskiTeresa BastanteRenicus S HermanidesWojciech WojakowskiEnrico FabrisJavier CuestaGiuseppe De LucaFernando Rivero-CrespoFernando AlfonsoElvin KedhiPublished in: European heart journal. Cardiovascular Imaging (2024)
In patients with DM and non-ischemic lesions, TCFA, h-PB, r-MLA and CP were predictors of adverse events. However, the presence of two or more OCT-VFs significantly increased the likelihood of MACE at 5 years. Further studies are warranted to confirm these findings and their potential clinical implications in a randomized fashion.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- risk factors
- coronary artery disease
- clinical trial
- study protocol
- heavy metals
- glycemic control
- phase iii
- optic nerve
- ischemia reperfusion injury
- type diabetes
- phase ii
- randomized controlled trial
- case control
- adipose tissue
- oxidative stress
- insulin resistance
- blood brain barrier
- double blind
- placebo controlled