A randomized controlled trial protocol assessing the effectiveness, safety and cost-effectiveness of methotrexate vs. ciclosporin in the treatment of severe atopic eczema in children: the TREatment of severe Atopic eczema Trial (TREAT).

Alan D IrvineA P JonesP BeattieS BaronF BrowneF AshoorL O'NeillA Rosala-HallasT SachC SpowartL TaamsC WalkerM WanN WebbP WilliamsonCarsten Flohrnull null

Published in: The British journal of dermatology (2018)

This trial addresses important therapeutic questions, highlighted in systematic reviews and treatment guidelines for atopic eczema. The trial design is pragmatic to reflect current clinical practice.

Keyphrases

study protocol
clinical practice
randomized controlled trial
atopic dermatitis
clinical trial
phase iii
phase ii
young adults
early onset
high dose
drug induced