Activity of Experimental Mouthwashes and Gels Containing DNA-RNA and Bioactive Molecules against the Oxidative Stress of Oral Soft Tissues: The Importance of Formulations. A Bioreactor-Based Reconstituted Human Oral Epithelium Model.
Andrei C IonescuElena VezzoliVincenzo ContePatrizia SartoriPatrizia ProcacciEugenio BrambillaPublished in: Molecules (Basel, Switzerland) (2021)
A mouthwash formulation with hydrolyzed DNA-RNA effectively protected against oxidative stress without additional enhancement by other bioactive molecules. Active compounds, such as hyaluronic acid, β-Glucan, allantoin, bisabolol, ruscogenin, and essential oils, showed a protective effect against oxidative stress, which was not synergistic with the one of DNA-RNA. Incorporation of surfactant agents showed a reduced, yet significant, cytotoxic effect.
Keyphrases
- oxidative stress
- nucleic acid
- circulating tumor
- hyaluronic acid
- cell free
- single molecule
- dna damage
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- endothelial cells
- gene expression
- drug delivery
- circulating tumor cells
- heat shock
- high density
- induced pluripotent stem cells
- pluripotent stem cells
- aqueous solution