Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy.
Hannan GaoYue WuJiyun ShiXin ZhangTianyu LiuBiao HuBing JiaYakun WanZhaofei LiuFan WangPublished in: Journal for immunotherapy of cancer (2021)
Our results demonstrated that 99mTc-MY1523 SPECT/CT allowed a real-time, quantitative and dynamic mapping of PD-L1 expression in vivo, and the imaging-guided PD-L1 blockade immunotherapy significantly enhanced the therapeutic efficacy. This strategy merits translation into clinical practice for the better management of combination therapies with radiotherapy or chemotherapy.
Keyphrases
- high resolution
- clinical practice
- locally advanced
- randomized controlled trial
- early stage
- computed tomography
- radiation therapy
- magnetic resonance
- stem cells
- magnetic resonance imaging
- mass spectrometry
- image quality
- contrast enhanced
- mesenchymal stem cells
- positron emission tomography
- dual energy
- fluorescence imaging
- chemotherapy induced