Lithium carbonate in amyotrophic lateral sclerosis patients homozygous for the C-allele at SNP rs12608932 in UNC13A: protocol for a confirmatory, randomized, group-sequential, event-driven, double-blind, placebo-controlled trial.

Sean W WillemseKit C B RoesPhilip Van DammeOrla HardimanCaroline IngreMonica PovedanoNaomi R WrayMarleen GijzenMirjam S de PagterKoen C DemaegdAnnemarie F C JanseRoel G VinkBoudewijn T H M SleutjesAdriano ChiòPhilippe CorciaEvy ReviersAmmar Al-ChalabiMatthew C KiernanLeonard H van den BergMichael A van EsRuben P A van Eijk

Published in: Trials (2022)

EudraCT number 2020-000579-19 . Registered on 29 March 2021.

Keyphrases

double blind
placebo controlled
clinical trial
ejection fraction
end stage renal disease
phase iii
newly diagnosed
randomized controlled trial
phase ii
open label
prognostic factors
genome wide
gene expression
patient reported outcomes
high density