From NOTIONs to nuances: TAVR and SAVR in low-risk patients.
Pradeep NarayanPublished in: Indian journal of thoracic and cardiovascular surgery (2024)
The NOTION trial, in this 10-year follow-up report, comprehensively compares transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) in low-risk patients. The study reveals similar outcomes in terms of mortality, stroke, and myocardial infarction. TAVR demonstrates advantages such as improved effective orifice area and transprosthetic gradients, along with reduced rates of new-onset atrial fibrillation. However, it is associated with higher rates of permanent pacemaker implantation and paravalvular leaks. Concerns exist regarding the generalizability of findings and unblinding during outcome assessments.
Keyphrases
- transcatheter aortic valve replacement
- aortic stenosis
- ejection fraction
- aortic valve
- aortic valve replacement
- transcatheter aortic valve implantation
- end stage renal disease
- atrial fibrillation
- chronic kidney disease
- newly diagnosed
- prognostic factors
- heart failure
- clinical trial
- left ventricular
- cardiovascular disease
- type diabetes
- randomized controlled trial
- metabolic syndrome
- percutaneous coronary intervention
- insulin resistance
- study protocol
- skeletal muscle
- patient reported
- weight loss
- venous thromboembolism
- vena cava
- direct oral anticoagulants