Phase Ib and Expansion Study of Gemcitabine, Nab-Paclitaxel, and Ficlatuzumab in Patients With Metastatic Pancreatic Cancer.
Kimberley J PerezAnna M ChiarellaJames M ClearyNora HorickColin WeekesThomas AbramsLawrence BlaszkowskyPeter EnzingerMarios GiannakisLipika GoyalJeffrey A MeyerhardtDouglas RubinsonMatthew B YurgelunWolfram GoesslingBruce J GiantonioLauren BraisVictoria GermonDanielle StonelySrivatsan RaghavanBasil BakirKoushik DasJason R PitarresiAndrew J AguirreMichael NeedleAnil K RustgiBrian M WolpinPublished in: The oncologist (2023)
In this phase Ib trial, ficlatuzumab, gemcitabine, and albumin-bound paclitaxel were associated with durable treatment responses and increased rates of hypoalbuminemia and edema.