Fibroblast growth factor (FGF), FGF receptor (FGFR), and cyclin D1 (CCND1) DNA methylation in head and neck squamous cell carcinomas is associated with transcriptional activity, gene amplification, human papillomavirus (HPV) status, and sensitivity to tyrosine kinase inhibitors.

Yilin BaoJennis GabrielpillaiJörn DietrichRomina ZarblSebastian StriethFriederike SchröckDimo Dietrich

Published in: Clinical epigenetics (2021)

Our results suggest an epigenetic regulation of CCND1, FGFRs, and FGFs via DNA methylation in HNSCC and warrants further investigation of DNA methylation as a potential predictive biomarker for response to selective FGFR inhibitors in clinical trials.

Keyphrases

dna methylation
genome wide
gene expression
squamous cell
clinical trial
copy number
high grade
transcription factor
randomized controlled trial
risk assessment
binding protein
oxidative stress
genome wide identification
climate change
human health
phase ii
cell cycle arrest
pi k akt