Phytoprostane and phenolic compounds from Chromolaena palmaris.
Mariana R Passos de SouzaAnderson V G RamosJosiane A Monteiro de OliveiraMárcia Regina Pereira CabralEloísa G SampironRegiane B de Lima ScodroMary Ann FoglioAna Lucia T G RuizMarta R B do CarmoMaria H SarragiottoDebora C BaldoquiPublished in: Natural product research (2021)
The chemical investigation of Chromolaena palmaris (Sch.Bip. ex Baker) R.M. King & H. Rob. expands the phytochemical composition knowledge of Chromolaena genus, since this is the first chemical investigation of this species. Twenty-five compounds were identified, including a phytoprostane, 17 flavonoids, 6 phenolic acids, and a caffeoyl-glucoside derivative obtained by classical chromatography and UHPLC-HRMS/MS analysis. Moreover, anti-Mycobacterium tuberculosis and antiproliferative activities of C. palmaris were evaluated. Dichloromethane fraction showed cytotoxicity towards human cancer cell lines, presenting TGI values on glioma (U251) of 27.8 μg mL-1. Furthermore, compounds 1 and 2 exhibited antimicrobial activity against Mycobacterium tuberculosis with MIC of 62.5 and 15.6 μg mL-1, respectively.
Keyphrases
- mycobacterium tuberculosis
- ms ms
- mass spectrometry
- endothelial cells
- pulmonary tuberculosis
- high resolution mass spectrometry
- liquid chromatography
- tandem mass spectrometry
- papillary thyroid
- healthcare
- multiple sclerosis
- squamous cell
- high speed
- simultaneous determination
- case report
- high performance liquid chromatography
- ultra high performance liquid chromatography
- pluripotent stem cells
- high resolution