CXCL1 contributes to IL-6 expression in osteoarthritis and rheumatoid arthritis synovial fibroblasts by CXCR2, c-Raf, MAPK, and AP-1 pathway.
Sheng-Mou HouPo-Chun ChenChieh-Mo LinMei-Ling FangMiao-Ching ChiJu-Fang LiuPublished in: Arthritis research & therapy (2020)
Our present work suggests that the CXCL1/CXCR2 axis helps to orchestrate inflammatory responses in OA and RA SFs.