Ipragliflozin Ameliorates Endoplasmic Reticulum Stress and Apoptosis through Preventing Ectopic Lipid Deposition in Renal Tubules.

Kohshiro HosokawaTomoaki TakataTakaaki SugiharaTomomitsu MatonoMasahiko KodaTsutomu KandaSosuke TaniguchiAyami IdaYukari MaeMarie YamamotoTakuji IyamaSatoko FukudaHajime Isomoto

Published in: International journal of molecular sciences (2019)

ELD induced kidney injury through ER stress. Ipragliflozin improved the pathogenesis of CKD by reducing ELD and ER stress in NASH-model mice. Our results suggest ipragliflozin has therapeutic effect on CKD in NASH.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
chronic kidney disease
high glucose
diabetic rats
high fat diet induced
mouse model
drug induced
fatty acid
type diabetes
adipose tissue
cell death