Application of Value Frameworks to the Design of Clinical Trials: The Canadian Cancer Trials Group Experience.
Joseph C Del PaggioAdam M FundytusWilma M HopmanJoseph L PaterBingshu E ChenMichael D BrundageAnnette E HayChristopher M BoothPublished in: Journal of the National Cancer Institute (2022)
Most CCTG phase III trials were designed to detect clinically meaningful differences in outcome, although less than one-half of positive trials met the threshold for substantial benefit. Application of value frameworks to the design of clinical trials is practical and may improve research efficiency and treatment options for patients.