Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis.

Clarice X LimAnna RedlLisa KleisslRam Vinay PandeyCarolina MayerhoferThomas El JammalMario MazicKarine GonzalesNyamdelger SukhbaatarThomas KrausgruberChristoph BockMarkus HengstschlägerAlain CalenderYves PachecoGeorg StaryThomas Weichhart

Published in: American journal of respiratory and critical care medicine (2024)

Together, our findings show that altered lipid metabolism in sarcoidosis macrophages is associated with its predisposition to granuloma formation and suggest cholesterol-reducing therapies as a treatment option in patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
fatty acid
patient reported outcomes
patient reported
combination therapy
low density lipoprotein