Gestational diabetes is driven by microbiota-induced inflammation months before diagnosis.
Yishay PintoSigal FrishmanSondra C TurjemanAdi EshelMeital Nuriel-OhayonOshrit ShrosselOren ZivWilliam WaltersJulie ParsonnetCatherine LeyElizabeth L JohnsonKrithika KumarRon SchweitzerSoliman KhatibFaiga MagzalEfrat MullerSnait TamirKinneret Tenenbaum-GavishSamuli RautavaSeppo SalminenErika IsolauriOr YarivYoav PeledEran PoranJoseph PardoRony ChenMoshe HodElhanan BorensteinRuth E LeyBetty SchwartzYoram LouzounEran HadarOmry KorenPublished in: Gut (2023)
GDM onset can be identified in the first trimester of pregnancy, earlier than currently accepted. Furthermore, the gut microbiome appears to play a role in inflammation-induced GDM pathogenesis, with interleukin-6 as a potential contributor to pathogenesis. Potential GDM markers, including microbiota, can serve as targets for early diagnostics and therapeutic intervention leading to prevention.